Utvalda publikationer

Carlson H, Ronne-Engström E, Ungerstedt U, Hillered L: Seizure related elevations of extracellular amino acids in the human epileptic focus. Neurosci Lett 140:30-32, 1992.

Enblad P, Valtysson J, Andersson J, Lilja A, Valind S, Antoni G, Långström B, Hillered L, Persson L: Simultaneous intracerebral microdialysis and positron emission tomography in the detection of ischemia in patients with subarachnoid hemorrhage. J Cereb Blood Flow Metab 16:637-644, 1996.

Frykholm P, Andersson JLR, Valtysson J, C:son Silander H, Hillered L, Persson L, Olsson Y,Wen RY, Westerberg G, Watanabe Y, Långström B, Enblad P: E metabolic threshold of irreversible ischemia demonstratedby PET in a middle cerebral artery occlusion-reperfusion primate model. Acta Neurol Scand 102:18-26, 2000.

Marklund N, Ostman B, Nalmo L, Persson L, Hillered L: Hypoxanthine, uric and allantoin as indicators of in vivo free radical reactrions. Description of a HPLC method and human brain microdialysis data. Acta Neurochir (Wien) 142:1135-1141, 2000.

Enblad P, Frykholm P, Valtysson J, Silander C:son H, Andersson J, Fasth KJ, Watanabe Y, Långström B, Hillered L, Persson L: Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomography. Stroke 32:1574-1580, 2001.

Lewén A, Skoglösa Y, Clausen F, Marklund N, Chan P, Lindholm D, Hillered L: Paradoxical increase in neuronal DNA fragmentation after neuroprotective free radical scanvenger treatment in experimental traumatic brain injury.  J Cerebr Blood Flow and Metabolism 21:344-350, 2001.

Marklund N, Clausen F, McIntosh TK, Hillered L: Free radical scavenger post-treatment improves functional and morphological outcome after fluid percussion injury in the rat. J Neurotrauma 18:821-832, 2001.

Marklund N, Lewander T, Clausen F, Hillered L; Effects of nitrone radical scavengers on in vivo trapping of reactive oxygen species after traumatic brain injury in rats., J Cerebr Blood Flow and Metab 21:1259-1267, 2001.

Marklund N, Clausen F, Lewander T, Hillered L: Monitoring of reative oxygen species production after traumatic brain injury in rats with microdialysis and the 4-hydroxybenzoic acid trappping method. J Neurotrauma 18:1217- 1227, 2001.

Ronne-Engström E, Cesarini KG, Enblad P, Hesselager G, Marklund N, Nilsson P, Salci K, Persson L, Hillered L: Intracerebral microdialysis in neuro¬intensive care: the use of urea as an endogenous reference compound. J Neurosurg 94:397-402, 2001.

Elf K, Nilsson P, Enblad P: Outcome after traumatic brain injury improved by an organized secondary insult program and standardized neurointensive care. Neurological Cricitcal Care, Crit Care Med 30:2129-2134, 2002.

Marklund N, Sihver S, Långström B, Bergström M, Hillered L: Effect of traumatic brain injury and nitrone radical scavengers on relative changes in regional cerebral blood flow and glucose uptake in rats. J Neurotrauma 19:1139-1153, 2002.

Glenn TC, Kelly DF, Boscardin JW, McArthur DL, Vespa P, Oertel M, Hovda DA, Bergsneider M, Hillered L, Martin NA: Energy dysfunction as a predictor of outcome after moderate or severe head injury: Indices of oxygen, glucose and lactate metabolism. J Cereb Blood Flow Metab 23:1239-1250, 2003.

Clausen F, Lundqvist H, Ekmark S, Lewén A, Ebendal T, Hillered L: Oxygen free radical-dependent activation of extracellular signal-regulated kinase mediates apoptosis-like cell death after traumatic brain injury. J Neurotrauma 21:1168-1182, 2004.

Ahlsson F, Gedeborg R, Hesselager G, Tuvemo T, Enblad P: Treatment of extreme hyperglycemia monitored with intracerebral microdialysis. Pediatr Crit Care Med 5:89-92, 2004.

Salci K, Enblad P, Piper I, Contant C, Nilsson P: A model for studies of intracranial volume pressure dynamics in traumatic brain injury. J Neurotrauma 21: 317- -327, 2004.

Clausen F, Hillered L: Intracranial pressure changes during fluid percussion, controlled cortical impact and weight drop injury in rats. Experimental Research. Acta Neurochir (Wien) 147:775-780, 2005.

Clausen F, Lewén A, Marklund N, Olsson Y, McArthur DL, Hillered L: Correlation of hippocampal morphological changes and Morris water maze performance after cortical contusion injury in rats. Neurosurgery 57:154-162, 2005.

Frykholm P, Hillered L, Långström B, Persson L, Valtysson J, Enblad P: Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: a microdialysis and positron emission tomography study in nonhuman primates. J Neurosurg 102:1076-1084, 2005.

Elf K, Nilsson P, Ronne-Engström E, Howells T, Enblad P: Cerebral perfusion pressure between 50 and 60 mm Hg may be beneficial in head-injured patients: A computerized secondary insult monitoring study. Neurosurgery 56:962-970, 2005.

Hillered, L, Vespa PM, Hovda DA: Translational neurochemical research in acute human brain injury: The current status and potential future for cerebral microdialysis – Invited  review (peer reviewed). J Neurotrauma 22:3-41, 2005.

Howells T, Elf K, Jones PA, Ronne-Engström E, Piper I, Nilsson P, Andrews P, Enblad P: Pressure reactivity as a guide in the treatment of cerebral perfusion pressure in patients with brain trauma. J Neurosurg 102:311-317, 2005.

Hillered L, Persson L, Nilsson P, Ronne-Engström E, Enblad P: Continuous monitoring of cerebral metabolism in traumatic brain injury: a focus on cerebral microdialysis. Curr Opin Crit Care 12:112-118, 2006.

Salci K, Nilsson P, Goiny M, Contant C, Piper I, Enblad P: Low intracranial compliance increases the impact of intracranial volume insults to the traumatized brain: A microdialysis study in a traumatic brain injury rodent model. Neurosurgery 59:367-372, 2006.

Clausen F, Lorant T, Lewén A, Hillered L: T Lymphocyte trafficking: A novel target for neuroprotection in traumatic brain injury. J Neurotrauma 24:1295-1307, 2007.

Samuelsson C, Hillered L, Zetterling M, Enblad P, Hesselager G, Ryttlefors M, Kumlien E, Lewén A, Marklund N, Nilsson P, Salci K, Ronne-Engström E: Cerebral glutamine and glutamate levels in relation to compromised energy metabolism: A microdialysis study in subarachnoid hemorrhage patients. J Cerebr Blood Flow Metab, 27:1309-1317, 2007.

Israelsson C, Bengtsson H, Kylberg A, Kullander K, Lewén A, Hillered L and Ebendal T: Distinct Cellular Patterns of Upregulated Chemokine Expression Supporting a Prominent Inflammatory Role in Traumatic Brain Injury J Neurotrauma 25:959-974, 2008.

Clausen F, Marklund N, Lewén A, Hillered L: The nitrone free radical scavenger NXY-059 is neuroprotective when administered after traumatic brain injury in the rat. J Neurotrauma 25 (12) 1449-1457, 2009.

Samuelsson C, Howells T, Kumlien E, Enblad E, Hillered L, Ronne-Engström E: Relationship between intracranial hemodynamics and microdialysis markers of energy metabolism and glutamate/glutamine turnover in subarachnoid hemorrhage patients. J Neurosurg 111:910-915, 2009.

Marklund N, Blennow K, Zetterberg H, Ronne-Engström E, Enblad P and Hillered L: Monitoring of Brain Interstitial Total Tau and β Amyloid Proteins by Microdialysis in Patients with Traumatic Brain Injury. J Neurosurg 110:1227-1237, 2009.

Hanrieder J, Wetterhall M, Enblad P, Hillered L and Bergquist J: Temporally resolved differential proteomics analysis of human ventricular CSF for monitoring traumatic brain injury biomarker candidates. J Neurosci Methods 177(2):469-78, 2009.

Israelsson C, Bengtsson H, Lobell A, Nilsson L, Kylberg A, Isaksson M, Wootz H, Lannfelt L, Kullander K, Hillered L and Ebendal T (2010) Appearance of Cxcl10 expressing cell clusters common for neurodegenerative disorders and traumatic brain injury. Eur J Neurosci 31:852-863.

Clausen F, Hånell A, Björk M, Hillered L, Mir AK, Gram H, Marklund N (2009) Neutralization of Interleukin-1β Modifies the Inflammatory Response and Improves Histological and Cognitive Outcome Following Traumatic Brain Injury in Mice. Eur J Neurosci 30(3):385-396.

Dahlin AP, Wetterhall M, Caldwell KD, Larsson A, Bergquist J, Hillered L and Hjort K: Methodological aspects on microdialysis protein sampling and quantification in biological fluids – An in vitro study on human ventricular CSF. Analytical Chemistry, 2010 (in press).

Wallenquist U, Brännvall K, Clausen F, Lewén A, Hillered L and Forsberg-Nilsson K: Grafted neural progenitors migrate and form neurons after experimental traumatic brain injury. Restorative Neurology and Neuroscience, 2010 (in press).

Ekmark-Lewén S, Lewén A, Israelsson C, Li G-L, Farooque M, Olsson Y, Ebendal T, Hillered L: Vimentin and GFAP responses in astrocytes after contusion trauma to the rat and mouse brain. Restorative neurology and neuroscience 2010 (in press).